Detalhe da pesquisa
1.
PI3K isoforms in cell signalling and vesicle trafficking.
Nat Rev Mol Cell Biol
; 20(9): 515-534, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31110302
2.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature
; 618(7963): 159-168, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225977
3.
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.
Nature
; 605(7911): 741-746, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35508656
4.
Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Nat Immunol
; 14(11): 1127-36, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24036998
5.
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
Nat Immunol
; 13(11): 1045-1054, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23023391
6.
PI3K signalling: the path to discovery and understanding.
Nat Rev Mol Cell Biol
; 13(3): 195-203, 2012 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22358332
7.
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.
PLoS Genet
; 17(11): e1009876, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34762647
8.
Endothelial phosphoinositide 3-kinase-ß inactivation confers protection from immune-mediated vascular injury.
Am J Transplant
; 23(2): 202-213, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36804130
9.
PI3KC2ß inactivation stabilizes VE-cadherin junctions and preserves vascular integrity.
EMBO Rep
; 22(6): e51299, 2021 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33880878
10.
Long-term treatment of cancer-prone germline PTEN mutant mice with low-dose rapamycin extends lifespan and delays tumour development.
J Pathol
; 258(4): 382-394, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36073856
11.
Idelalisib inhibits experimental proliferative vitroretinopathy.
Lab Invest
; 102(12): 1296-1303, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35854067
12.
Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion.
Br J Cancer
; 127(9): 1595-1602, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35986086
13.
The emerging mechanisms of isoform-specific PI3K signalling.
Nat Rev Mol Cell Biol
; 11(5): 329-41, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20379207
14.
Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation.
J Immunol
; 205(1): 78-89, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32414808
15.
Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.
Proc Natl Acad Sci U S A
; 116(17): 8380-8389, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30948643
16.
Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α.
Genes Dev
; 28(23): 2621-35, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25452273
17.
Pharmacological and cell-specific genetic PI3Kα inhibition worsens cardiac remodeling after myocardial infarction.
J Mol Cell Cardiol
; 157: 17-30, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33887328
18.
Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach.
Br J Cancer
; 125(4): 467-469, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33824480
19.
Uninephrectomy and class II PI3K-C2ß inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice.
Am J Transplant
; 21(8): 2688-2697, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33370494
20.
Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus.
Mol Ther
; 28(5): 1263-1275, 2020 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32145202